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TIAL1 & TIA Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q01085 |
| Other Accession | NP_003243.1, NP_001029097.1, 7073, 7072, 21843 (mouse) |
| Reactivity | Human |
| Predicted | Mouse, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 41591 Da |
| Gene ID | 7073 |
|---|---|
| Other Names | Nucleolysin TIAR, TIA-1-related protein, TIAL1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TIAL1 & TIA Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TIAL1 |
|---|---|
| Function | RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (PubMed:1326761, PubMed:8576255, PubMed:17488725, PubMed:10613902). Shows a preference for uridine-rich RNAs (PubMed:8576255). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 (PubMed:17488725). Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (PubMed:10613902). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1326761). May be involved in apoptosis (PubMed:1326761). |
| Cellular Location | Nucleus. Cytoplasm {ECO:0000250|UniProtKB:P70318}. Cytolytic granule. Cytoplasm, Stress granule Note=Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (By similarity) Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:10613902). {ECO:0000250|UniProtKB:P70318, ECO:0000269|PubMed:10613902} |
| Tissue Location | Expressed in brain, heart, kidney, lung and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both isoforms (NP_003243.1; NP_001029097.1).
References
TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2. Yeowell HN, Walker LC, Mauger DM, Seth P, Garcia-Blanco MA, The Journal of investigative dermatology 2009 Jun 129 (6): 1402-11. PMID: 19110540
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