|Application ||WB, IHC, E|
|Other Accession||NP_003243.1, NP_001029097.1, 7073, 7072, 21843 (mouse)|
|Predicted||Mouse, Dog, Cow|
|Calculated MW||41591 Da|
|Other Names||Nucleolysin TIAR, TIA-1-related protein, TIAL1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TIAL1 & TIA Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both isoforms (NP_003243.1; NP_001029097.1).
TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2. Yeowell HN, Walker LC, Mauger DM, Seth P, Garcia-Blanco MA, The Journal of investigative dermatology 2009 Jun 129 (6): 1402-11. PMID: 19110540
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