|Application ||WB, E|
|Other Accession||NP_056474.2, 26156|
|Calculated MW||54973 Da|
|Other Names||Ribosomal L1 domain-containing protein 1, CATX-11, Cellular senescence-inhibited gene protein, Protein PBK1, RSL1D1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RSL1D1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.|
|Cellular Location||Nucleus, nucleolus Note=Colocalizes with ING1 in the nucleolus after UV stress|
|Tissue Location||Expressed at high intensities in the heart, skeletal muscle, and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
CSIG inhibits PTEN translation in replicative senescence. Ma L, Chang N, Guo S, Li Q, Zhang Z, Wang W, Tong T, Molecular and cellular biology 2008 Oct 28 (20): 6290-301. PMID: 18678645
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