|Other Accession||NP_071910.3, 64375, 22781 (mouse)|
|Predicted||Human, Mouse, Dog, Cow|
|Calculated MW||64106 Da|
|Other Names||Zinc finger protein Eos, Ikaros family zinc finger protein 4, IKZF4, KIAA1782, ZNFN1A4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IKZF4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T- cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).|
|Tissue Location||Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K- 562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.|
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A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. Hakonarson H, Qu HQ, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton EC, Eckert AW, Annaiah K, Lawson ML, Otieno FG, Santa E, Shaner JL, Smith RM, Onyiah CC, Skraban R, Chiavacci RM, Robinson LJ, Stanley CA, Kir Diabetes 2008 Apr 57 (4): 1143-6. PMID: 18198356
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