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TRIM29 / ATDC Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q14134 |
| Other Accession | NP_036233.2, 23650, 72169 (mouse), 300656 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 65835 Da |
| Gene ID | 23650 |
|---|---|
| Other Names | Tripartite motif-containing protein 29, Ataxia telangiectasia group D-associated protein, TRIM29, ATDC |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIM29 / ATDC Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM29 |
|---|---|
| Synonyms | ATDC |
| Function | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. |
| Cellular Location | Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments |
| Tissue Location | Expressed in placenta, prostate and thymus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization. Wang L, Heidt DG, Lee CJ, Yang H, Logsdon CD, Zhang L, Fearon ER, Ljungman M, Simeone DM, Cancer cell 2009 Mar 15 (3): 207-19. PMID: 19249679
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