|Other Accession||NP_078808.3, NP_001020607.1, 79582|
|Predicted||Human, Dog, Cow|
|Calculated MW||70818 Da|
|Other Names||Sperm-associated antigen 16 protein, Pf20 protein homolog, SPAG16, PF20|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPAG16 (aa139-152) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium axoneme. Note=Detected on the sperm flagellum axoneme. Detected in the central apparatus of the axoneme. Colocalizes with SPAG6 on microtubules (By similarity)|
|Tissue Location||Isoform 1 is detected in testis. Isoform 4 is detected in testis and brain, and at lower levels in kidney, heart, pancreas, thyroid, ovary, adrenal gland, spinal cord, trachea and liver.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize isoform 1 and 2 (NP_078808.3; NP_001020607.1).
A heterozygous mutation disrupting the SPAG16 gene results in biochemical instability of central apparatus components of the human sperm axoneme. Zhang Z, Zariwala MA, Mahadevan MM, Caballero-Campo P, Shen X, Escudier E, Duriez B, Bridoux AM, Leigh M, Gerton GL, Kennedy M, Amselem S, Knowles MR, Strauss JF, Biology of reproduction 2007 Nov 77 (5): 864-71. PMID: 17699735
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