|Application ||WB, E|
|Other Accession||NP_002417.2, 4321|
|Calculated MW||54002 Da|
|Other Names||Macrophage metalloelastase, MME, 126.96.36.199, Macrophage elastase, ME, hME, Matrix metalloproteinase-12, MMP-12, MMP12, HME|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MMP12 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Found in alveolar macrophages but not in peripheral blood monocytes|
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Association of MMP1, MMP3, MMP9, and MMP12 polymorphisms with risk and clinical course of multiple sclerosis in a Polish population. Mirowska-Guzel D, Gromadzka G, Czlonkowski A, Czlonkowska A, Journal of neuroimmunology 2009 Sep 214 (1-2): 113-7. PMID: 19628284
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