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NALP2 / PAN1 Antibody (C-Term, near)

Peptide-affinity purified goat antibody

  • WB - NALP2 / PAN1 Antibody (C-Term, near) AF3137a
    HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human NLRP2 with DYKDDDDK tag probed with AF3137a (1ug/ml) in Lane A and probed with anti- DYKDDDDK Tag (1/5000) in lane C. Mock-transfected HEK293 probed with AF3137a (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NX02
Other Accession NP_060322.1, 55655
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 120515 Da
Additional Information
Gene ID 55655
Other Names NACHT, LRR and PYD domains-containing protein 2, Nucleotide-binding site protein 1, PYRIN domain and NACHT domain-containing protein 1, PYRIN-containing APAF1-like protein 2, NLRP2, NALP2, NBS1, PAN1, PYPAF2
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNALP2 / PAN1 Antibody (C-Term, near) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRP2
Synonyms NALP2, NBS1, PAN1, PYPAF2
Function Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
Cellular Location Cytoplasm
Tissue Location Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain
Research Areas
Citations (0)

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Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells. Ji S, Shin JE, Kim YS, Oh JE, Min BM, Choi Y, Infection and immunity 2009 Mar 77 (3): 1044-52. PMID: 19103770

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$ 325.00
Cat# AF3137a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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