|Application ||WB, E|
|Other Accession||NP_060322.1, 55655|
|Calculated MW||120515 Da|
|Other Names||NACHT, LRR and PYD domains-containing protein 2, Nucleotide-binding site protein 1, PYRIN domain and NACHT domain-containing protein 1, PYRIN-containing APAF1-like protein 2, NLRP2, NALP2, NBS1, PAN1, PYPAF2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NALP2 / PAN1 Antibody (C-Term, near) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||NALP2, NBS1, PAN1, PYPAF2|
|Function||Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.|
|Tissue Location||Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain|
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Provided below are standard protocols that you may find useful for product applications.
Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells. Ji S, Shin JE, Kim YS, Oh JE, Min BM, Choi Y, Infection and immunity 2009 Mar 77 (3): 1044-52. PMID: 19103770
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