SIT1 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q9Y3P8 |
Other Accession | NP_055265.1, 27240 |
Predicted | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 21126 Da |
Gene ID | 27240 |
---|---|
Other Names | Signaling threshold-regulating transmembrane adapter 1, SHP2-interacting transmembrane adapter protein, Suppression-inducing transmembrane adapter 1, gp30/40, SIT1, SIT |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SIT1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SIT1 |
---|---|
Synonyms | SIT |
Function | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells. |
Cellular Location | Cell membrane; Single-pass type I membrane protein |
Tissue Location | Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level) Expressed in T- and B-cell lymphoma. |
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Provided below are standard protocols that you may find useful for product applications.
References
SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation. Marie-Cardine A, Kirchgessner H, Bruyns E, Shevchenko A, Mann M, Autschbach F, Ratnofsky S, Meuer S, Schraven B, The Journal of experimental medicine 1999 Apr 189 (8): 1181-94. PMID: 10209036
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