|Application ||WB, E|
|Other Accession||NP_003293.2, 7205|
|Calculated MW||50288 Da|
|Other Names||Thyroid receptor-interacting protein 6, TR-interacting protein 6, TRIP-6, Opa-interacting protein 1, OIP-1, Zyxin-related protein 1, ZRP-1, TRIP6, OIP1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIP6 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm|
|Tissue Location||Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors|
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Provided below are standard protocols that you may find useful for product applications.
IL-12 stimulates the osteoclast inhibitory peptide-1 (OIP-1/hSca) gene expression in CD4+ T cells. Shanmugarajan S, Kawanabe N, Koide M, Tsuruga E, Arroyo JE, Key LL, Reddy SV, Journal of cellular biochemistry 2009 May 107 (1): 104-11. PMID: 19259951
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