TRIP6 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q15654 |
Other Accession | NP_003293.2, 7205 |
Reactivity | Human |
Predicted | Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 50288 Da |
Gene ID | 7205 |
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Other Names | Thyroid receptor-interacting protein 6, TR-interacting protein 6, TRIP-6, Opa-interacting protein 1, OIP-1, Zyxin-related protein 1, ZRP-1, TRIP6, OIP1 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TRIP6 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TRIP6 |
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Synonyms | OIP1 |
Function | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF- kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. |
Cellular Location | Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Cytoplasm Note=Shuttles between nucleus and cytoplasm (PubMed:16624523) Colocalizes with actin (PubMed:10826496). |
Tissue Location | Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors |
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Provided below are standard protocols that you may find useful for product applications.
References
IL-12 stimulates the osteoclast inhibitory peptide-1 (OIP-1/hSca) gene expression in CD4+ T cells. Shanmugarajan S, Kawanabe N, Koide M, Tsuruga E, Arroyo JE, Key LL, Reddy SV, Journal of cellular biochemistry 2009 May 107 (1): 104-11. PMID: 19259951
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