|Application ||WB, E|
|Other Accession||NP_004468.1, 2483, 14300 (mouse), 361156 (rat)|
|Calculated MW||29172 Da|
|Other Names||Protein FRG1, FSHD region gene 1 protein, FRG1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FRG1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N- methyltransferase SUV420H1.|
|Cellular Location||Nucleus, Cajal body. Nucleus, nucleolus. Cytoplasm. Cytoplasm, myofibril, sarcomere, Z line Note=Localization changes during myogenesis from mainly cytoplasmic in undifferentiated myoblasts, to strongly nucleolar in early myotubes and back to cytoplasmic 5 days post- differentiation. Localized at the Z-line in the sarcomere of matured myotubes 8 days post-differentiation|
|Tissue Location||Expressed in adult muscle, lymphocytes, fetal brain, muscle, and placenta. Also expressed in the smooth muscle of arteries and veins, the sweat glands and the epidermis|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Muscular dystrophy candidate gene FRG1 is critical for muscle development. Hanel ML, Wuebbles RD, Jones PL, Developmental dynamics : an official publication of the American Association of Anatomists 2009 Jun 238 (6): 1502-12. PMID: 19097195
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