|Other Accession||NP_001035049.1, NP_004849.2, 9498, 59033 (mouse), 315311 (rat)|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||122938 Da|
|Other Names||Electroneutral sodium bicarbonate exchanger 1, Electroneutral Na(+)-driven Cl-HCO3 exchanger, Solute carrier family 4 member 8, k-NBC3, S4A8|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC4A8 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize isoform a and b (NP_001035049.1; NP_004849.2).
Cloning and characterization of novel human SLC4A8 gene products encoding Na+-driven Cl-/HCO3(-) exchanger variants NDCBE-A, -C, and -D. Parker MD, Bouyer P, Daly CM, Boron WF, Physiological genomics 2008 Aug 34 (3): 265-76. PMID: 18577713
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