|Application ||WB, E|
|Other Accession||NP_034223.1, 1871, 13557 (mouse)|
|Calculated MW||49162 Da|
|Other Names||Transcription factor E2F3, E2F-3, E2F3, KIAA0075|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||E2F3 (mouse) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
The E2F1-3 transcription factors are essential for cellular proliferation. Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G, Nature 2001 Nov 414 (6862): 457-62. PMID: 11719808
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