|Application ||WB, E|
|Other Accession||NP_001941.2, 1874, 104394 (mouse)|
|Predicted||Mouse, Dog, Cow|
|Calculated MW||43960 Da|
|Other Names||Transcription factor E2F4, E2F-4, E2F4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||E2F4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.|
|Tissue Location||Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas|
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Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. Lu Y, DollÃ© ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM, Journal of lipid research 2008 Dec 49 (12): 2582-9. PMID: 18660489
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