|Application ||WB, IHC, E|
|Other Accession||NP_477520.2, NP_001139266.1, 118429|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||53666 Da|
|Other Names||Anthrax toxin receptor 2, Capillary morphogenesis gene 2 protein, CMG-2, ANTXR2, CMG2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ANTXR2 / CMG2 Antibody (internal regoin) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for cellular interactions with laminin and the extracellular matrix.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Expressed at the cell surface Isoform 3: Secreted.|
|Tissue Location||Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_477520.2; NP_001139266.1).
Systemic hyalinosis mutations in the CMG2 ectodomain leading to loss of function through retention in the endoplasmic reticulum. Deuquet J, Abrami L, Difeo A, Ramirez MC, Martignetti JA, van der Goot FG, Human mutation 2009 Apr 30 (4): 583-9. PMID: 19191226
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