|Application ||WB, E|
|Other Accession||NP_004632.1, NP_001009569.1, 8028, 17354 (mouse), 361285 (rat)|
|Predicted||Human, Mouse, Dog, Cow|
|Calculated MW||113320 Da|
|Other Names||Protein AF-10, ALL1-fused gene from chromosome 10 protein, MLLT10, AF10|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MLLT10 / AF10 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.|
|Tissue Location||Expressed abundantly in testis.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_004632.1; NP_001009569.1).
Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias. Lin YH, Kakadia PM, Chen Y, Li YQ, Deshpande AJ, Buske C, Zhang KL, Zhang Y, Xu GL, Bohlander SK, Blood 2009 Jul 114 (3): 651-8. PMID: 19443658
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