POU3F3 / BRN1 / OCT8 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P20264 |
Other Accession | NP_006227.1, 5455, 18993 (mouse), 192109 (rat) |
Reactivity | Mouse, Rat |
Predicted | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 50327 Da |
Gene ID | 5455 |
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Other Names | POU domain, class 3, transcription factor 3, Brain-specific homeobox/POU domain protein 1, Brain-1, Brn-1, Octamer-binding protein 8, Oct-8, Octamer-binding transcription factor 8, OTF-8, POU3F3, BRN1, OTF8 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | POU3F3 / BRN1 / OCT8 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | POU3F3 (HGNC:9216) |
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Synonyms | BRN1, OTF8 |
Function | Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development (PubMed:31303265). Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT- 3') (By similarity). |
Cellular Location | Nucleus. |
Tissue Location | Brain.. |
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Provided below are standard protocols that you may find useful for product applications.
References
Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Castro DS, Skowronska-Krawczyk D, Armant O, Donaldson IJ, Parras C, Hunt C, Critchley JA, Nguyen L, Gossler A, Göttgens B, Matter JM, Guillemot F, Developmental cell 2006 Dec 11 (6): 831-44. PMID: 17141158
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