|Application ||WB, E|
|Other Accession||NP_006227.1, 5455, 18993 (mouse), 192109 (rat)|
|Calculated MW||50327 Da|
|Other Names||POU domain, class 3, transcription factor 3, Brain-specific homeobox/POU domain protein 1, Brain-1, Brn-1, Octamer-binding protein 8, Oct-8, Octamer-binding transcription factor 8, OTF-8, POU3F3, BRN1, OTF8|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||POU3F3 / BRN1 / OCT8 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Castro DS, Skowronska-Krawczyk D, Armant O, Donaldson IJ, Parras C, Hunt C, Critchley JA, Nguyen L, Gossler A, GÃ¶ttgens B, Matter JM, Guillemot F, Developmental cell 2006 Dec 11 (6): 831-44. PMID: 17141158
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