|Application ||WB, E|
|Other Accession||NP_002691.1, 5459|
|Calculated MW||37052 Da|
|Other Names||POU domain, class 4, transcription factor 3, Brain-specific homeobox/POU domain protein 3C, Brain-3C, Brn-3C, POU4F3, BRN3C|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||POU4F3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional activator (PubMed:18228599). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:18228599). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=Preferentially localized in the nucleus.|
|Tissue Location||Brain. Seems to be specific to the retina.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected not to cross-react to the similar POU4F1 and POU4F2.
Vestibular impairment in a Dutch DFNA15 family with an L289F mutation in POU4F3. van Drunen FJ, Pauw RJ, Collin RW, Kremer H, Huygen PL, Cremers CW, Audiology & neuro-otology 2009 14 (5): 303-7. PMID: 19372648
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