POU4F3 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q15319 |
Other Accession | NP_002691.1, 5459 |
Reactivity | Human, Mouse |
Predicted | Rat, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 37052 Da |
Gene ID | 5459 |
---|---|
Other Names | POU domain, class 4, transcription factor 3, Brain-specific homeobox/POU domain protein 3C, Brain-3C, Brn-3C, POU4F3, BRN3C |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | POU4F3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | POU4F3 |
---|---|
Synonyms | BRN3C |
Function | Acts as a transcriptional activator (PubMed:18228599). Acts by binding to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:18228599). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity). |
Cellular Location | Nucleus. Cytoplasm Note=Preferentially localized in the nucleus |
Tissue Location | Brain. Seems to be specific to the retina. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected not to cross-react to the similar POU4F1 and POU4F2.
References
Vestibular impairment in a Dutch DFNA15 family with an L289F mutation in POU4F3. van Drunen FJ, Pauw RJ, Collin RW, Kremer H, Huygen PL, Cremers CW, Audiology & neuro-otology 2009 14 (5): 303-7. PMID: 19372648
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