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MEIS2 Antibody (internal region)

Peptide-affinity purified goat antibody

  • WB - MEIS2 Antibody (internal region) AF3212a
    AF3212a (0.1 µg/ml) staining of Mouse Brain (lane A), Rat Brain (lane B), Mouse Thymus (lane C) and Rat Thymus (lane D) lysates (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O14770
Other Accession NP_733777.1, NP_733775.1, NP_758526.1, 4212
Reactivity Mouse, Rat
Predicted Human, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 51790 Da
Additional Information
Gene ID 4212
Other Names Homeobox protein Meis2, Meis1-related protein 1, MEIS2, MRG1
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMEIS2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MEIS2
Synonyms MRG1
Function Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3/Meis2B and isoform 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5/Meis2E cannot activate DRD1 transcription.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}
Tissue Location Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen
Research Areas
Citations (0)

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This antibody is expected to recognize reported Human isoforms a (NP_733777.1), c (NP_733775.1), and g (NP_758526.1), and reported Mouse isoforms 3, 4 and 5 (NP_001153039.1, NP_001153040.1, NP_001153041.1). NB: The immunizing peptide shows no overlap with


Conserved regulation of proximodistal limb axis development by Meis1/Hth. Mercader N, Leonardo E, Azpiazu N, Serrano A, Morata G, Martínez C, Torres M, Nature 1999 Nov 402 (6760): 425-9. PMID: 10586884

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$ 325.00
Cat# AF3212a
(40 western blots)
Availability: 7-10 days
Bulk Size
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