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NIPBL (aa889-902) Antibody (internal region)

Peptide-affinity purified goat antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, E
Primary Accession Q6KC79
Other Accession NP_597677.2, NP_056199.2, 25836, 71175 (mouse), 294787 (rat)
Reactivity Mouse
Predicted Human, Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 316051 Da
Additional Information
Gene ID 25836
Other Names Nipped-B-like protein, Delangin, SCC2 homolog, NIPBL, IDN3
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNIPBL (aa889-902) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NIPBL
Synonyms IDN3, SCC2 {ECO:0000303|PubMed:22628566}
Function Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitement to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitement to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity).
Cellular Location Nucleus. Chromosome {ECO:0000250|UniProtKB:Q6KCD5}
Tissue Location Widely expressed. Highly expressed in heart, skeletal muscle, fetal and adult liver, fetal and adult kidney Expressed at intermediates level in thymus, placenta, peripheral leukocyte and small intestine. Weakly or not expressed in brain, colon, spleen and lung.
Research Areas
Citations (0)

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Background

This antibody is expected to recognize both reported isoforms (NP_597677.2; NP_056199.2).

References

Transcriptional dysregulation in NIPBL and cohesin mutant human cells. Liu J, Zhang Z, Bando M, Itoh T, Deardorff MA, Clark D, Kaur M, Tandy S, Kondoh T, Rappaport E, Spinner NB, Vega H, Jackson LG, Shirahige K, Krantz ID, PLoS biology 2009 May 7 (5): e1000119. PMID: 19468298

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$ 335.00
Cat# AF3215a
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