|Application ||IHC, E|
|Other Accession||NP_597677.2, NP_056199.2, 25836, 71175 (mouse), 294787 (rat)|
|Predicted||Human, Rat, Dog, Cow|
|Calculated MW||316051 Da|
|Other Names||Nipped-B-like protein, Delangin, SCC2 homolog, NIPBL, IDN3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NIPBL (aa889-902) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity).|
|Tissue Location||Widely expressed. Highly expressed in heart, skeletal muscle, fetal and adult liver, fetal and adult kidney Expressed at intermediates level in thymus, placenta, peripheral leukocyte and small intestine. Weakly or not expressed in brain, colon, spleen and lung.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_597677.2; NP_056199.2).
Transcriptional dysregulation in NIPBL and cohesin mutant human cells. Liu J, Zhang Z, Bando M, Itoh T, Deardorff MA, Clark D, Kaur M, Tandy S, Kondoh T, Rappaport E, Spinner NB, Vega H, Jackson LG, Shirahige K, Krantz ID, PLoS biology 2009 May 7 (5): e1000119. PMID: 19468298
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