|Application ||WB, E|
|Other Accession||NP_003582.2, 8453, 71745 (mouse), 361258 (rat)|
|Predicted||Human, Rat, Dog, Cow|
|Calculated MW||86983 Da|
|Other Names||Cullin-2, CUL-2, CUL2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CUL2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).|
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Provided below are standard protocols that you may find useful for product applications.
KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. Argyropoulos G, StÃ¼tz AM, Ilnytska O, Rice T, Teran-Garcia M, Rao DC, Bouchard C, Rankinen T, Physiological genomics 2009 Jan 36 (2): 79-88. PMID: 18984674
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