|Application ||WB, IHC, E|
|Other Accession||NP_002896.2, 5959, 19682 (mouse)|
|Calculated MW||34979 Da|
|Other Names||11-cis retinol dehydrogenase, 11-cis RDH, 11-cis RoDH, 220.127.116.115, 9-cis retinol dehydrogenase, 9cRDH, RDH5, RDH1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RDH5 (aa 19-31) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HSD17B9, RDH1, SDR9C5|
|Function||Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all- trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP.|
|Cellular Location||Membrane; Peripheral membrane protein Endoplasmic reticulum lumen|
|Tissue Location||Abundant in the retinal pigment epithelium. Expressed at high levels in mammary tissue, kidney and testis, and at lower levels in liver, heart, adrenal gland, lung, pancreas and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U. Chemico-biological interactions 2009 Mar 178 (1-3): 94-8. PMID: 19027726
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