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PEX6 Antibody (C-Term)

Peptide-affinity purified goat antibody

     
  • WB - PEX6 Antibody (C-Term) AF3228a
    AF3228a (0.3 µg/ml) staining of Rat Liver lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q13608
Other Accession NP_000278.3, 5190, 224824 (mouse), 117265 (rat)
Reactivity Rat
Predicted Human, Mouse, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 104061 Da
Additional Information
Gene ID 5190
Other Names Peroxisome assembly factor 2, PAF-2, Peroxin-6, Peroxisomal biogenesis factor 6, Peroxisomal-type ATPase 1, PEX6, PXAAA1
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPEX6 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PEX6 {ECO:0000303|PubMed:10408779, ECO:0000312|HGNC:HGNC:8859}
Function Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:16314507, PubMed:16854980, PubMed:21362118, PubMed:29884772). Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2- PEX10-PEX12 retrotranslocation channel (PubMed:29884772). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed:29884772).
Cellular Location Cytoplasm, cytosol. Peroxisome membrane. Cell projection, cilium, photoreceptor outer segment. Note=Associated with peroxisomal membranes; anchored by PEX26 to peroxisome membranes (PubMed:12717447, PubMed:16854980). Localized at the base of the outer segment of photoreceptor cells (PubMed:26593283)
Tissue Location Expressed in the retina, at higher levels in the photoreceptor layer at the joint between the outer and inner segments
Research Areas
Citations (0)
citation

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References

Maternally inherited Leigh syndrome: T8993G mutation in a Tunisian family. Mkaouar-Rebai E, Chaari W, Younes S, Bousoffara R, Sfar MT, Fakhfakh F, Pediatric neurology 2009 Jun 40 (6): 437-42. PMID: 19433277

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$ 341.00
Cat# AF3228a
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