|Application ||WB, E|
|Other Accession||NP_077734.1, 5321|
|Calculated MW||85239 Da|
|Other Names||Cytosolic phospholipase A2, cPLA2, Phospholipase A2 group IVA, Phospholipase A2, 188.8.131.52, Phosphatidylcholine 2-acylhydrolase, Lysophospholipase, 184.108.40.206, PLA2G4A, CPLA2, PLA2G4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLA2G4A Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.|
|Cellular Location||Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion|
|Tissue Location||Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium|
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Provided below are standard protocols that you may find useful for product applications.
JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2. Gubern A, Barceló-Torns M, Barneda D, López JM, Masgrau R, Picatoste F, Chalfant CE, Balsinde J, Balboa MA, Claro E, The Journal of biological chemistry 2009 Nov 284 (47): 32359-69. PMID: 19778898
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