|Application ||IHC, E|
|Other Accession||NP_004406.2, 1832, 109620 (mouse), 306871 (rat)|
|Calculated MW||331774 Da|
|Other Names||Desmoplakin, DP, 250/210 kDa paraneoplastic pemphigus antigen, DSP|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Desmoplakin (aa 1672 -1684) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.|
|Cellular Location||Cell junction, desmosome. Cytoplasm, cytoskeleton. Note=Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network|
|Tissue Location||Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize reported isoform I (NP_004406.2) only.
Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia. Barahona-Dussault C, Benito B, Campuzano O, Iglesias A, Leung TL, Robb L, Talajic M, Brugada R, Clinical genetics 2010 Jan 77 (1): 37-48. PMID: 19863551
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