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Desmoplakin (aa 1546-1558) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | P15924 |
| Other Accession | NP_004406.2, 1832, 109620 (mouse), 306871 (rat) |
| Predicted | Human, Mouse, Rat, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 331774 Da |
| Gene ID | 1832 |
|---|---|
| Other Names | Desmoplakin, DP, 250/210 kDa paraneoplastic pemphigus antigen, DSP |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Desmoplakin (aa 1546-1558) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DSP |
|---|---|
| Function | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). |
| Cellular Location | Cell junction, desmosome {ECO:0000250|UniProtKB:E9Q557}. Cell membrane {ECO:0000250|UniProtKB:E9Q557}. Note=Localizes at the intercalated disk in cardiomyocytes. {ECO:0000250|UniProtKB:E9Q557} |
| Tissue Location | Expressed in oral mucosa (at protein level) (PubMed:30479852). Expressed in arrector pili muscle (at protein level) (PubMed:29034528). [Isoform DPII]: Resides predominantly in tissues and cells of stratified origin |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize reported isoform I (NP_004406.2) only.
References
Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia. Barahona-Dussault C, Benito B, Campuzano O, Iglesias A, Leung TL, Robb L, Talajic M, Brugada R, Clinical genetics 2010 Jan 77 (1): 37-48. PMID: 19863551
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