|Application ||WB, E|
|Other Accession||NP_004997.4, 4719, 227197 (mouse), 301458 (rat)|
|Predicted||Rat, Rabbit, Dog, Cow|
|Calculated MW||79468 Da|
|Other Names||NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial, 188.8.131.52, 184.108.40.206, Complex I-75kD, CI-75kD, NDUFS1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NDUFS1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized.|
|Cellular Location||Mitochondrion inner membrane.|
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Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. Saito A, Kawamoto M, Kamatani N, Journal of human genetics 2009 Jun 54 (6): 317-23. PMID: 19343046
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