|Application ||WB, E|
|Other Accession||NP_004541.1, NP_001159631.1, 4720, 226646 (mouse), 289218 (rat)|
|Reactivity||Human, Mouse, Rat|
|Predicted||Rabbit, Pig, Dog, Cow|
|Calculated MW||52546 Da|
|Other Names||NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial, 184.108.40.206, 220.127.116.11, Complex I-49kD, CI-49kD, NADH-ubiquinone oxidoreductase 49 kDa subunit, NDUFS2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NDUFS2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).|
|Cellular Location||Mitochondrion inner membrane; Peripheral membrane protein; Matrix side|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_004541.1; NP_001159631.1).
Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease. Saada A, Vogel RO, Hoefs SJ, van den Brand MA, Wessels HJ, Willems PH, Venselaar H, Shaag A, Barghuti F, Reish O, Shohat M, Huynen MA, Smeitink JA, van den Heuvel LP, Nijtmans LG, American journal of human genetics 2009 Jun 84 (6): 718-27. PMID: 19463981
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