|Application ||WB, E|
|Other Accession||NP_001167.2, 398, 14570 (mouse), 360500 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||25098 Da|
|Other Names||Rho GDP-dissociation inhibitor 3, Rho GDI 3, Rho-GDI gamma, ARHGDIG|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARHGDIG Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.|
|Tissue Location||Primarily expressed in pancreas and brain.|
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Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve. Wooten EC, Iyer LK, Montefusco MC, Hedgepeth AK, Payne DD, Kapur NK, Housman DE, Mendelsohn ME, Huggins GS, PloS one 2010 5 (1): e8830. PMID: 20098615
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