|Application ||WB, IHC, E|
|Other Accession||NP_001271.1, 1153, 12696 (mouse), 81825 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||18648 Da|
|Other Names||Cold-inducible RNA-binding protein, A18 hnRNP, Glycine-rich RNA-binding protein CIRP, CIRBP, A18HNRNP, CIRP|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CIRBP (aa 161-172) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold- induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.|
|Cellular Location||Nucleus, nucleoplasm. Cytoplasm. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).|
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Down-regulating cold shock protein genes impairs cancer cell survival and enhances chemosensitivity. Zeng Y, Kulkarni P, Inoue T, Getzenberg RH, Journal of cellular biochemistry 2009 May 107 (1): 179-88. PMID: 19277990
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