SPINT2 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | O43291 |
Other Accession | NP_066925.1, NP_001159575.1, 10653, 20733 (mouse), 292770 (rat) |
Reactivity | Human |
Predicted | Mouse, Rat, Dog, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 28228 Da |
Gene ID | 10653 |
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Other Names | Kunitz-type protease inhibitor 2, Hepatocyte growth factor activator inhibitor type 2, HAI-2, Placental bikunin, SPINT2, HAI2, KOP |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SPINT2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SPINT2 |
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Synonyms | HAI2, KOP |
Function | Inhibitor of HGFAC (PubMed:9346890). Also inhibits plasmin, and plasma and tissue kallikrein (PubMed:9115294). Inhibits serine protease activity of TMPRSS13 (PubMed:20977675, PubMed:28710277). Inhibits serine protease activity of ST14/matriptase in vitro (PubMed:28710277). |
Cellular Location | Cell membrane; Single-pass type I membrane protein. Cytoplasm |
Tissue Location | Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize to recognize both reported isoforms (NP_066925.1; NP_001159575.1).
References
Case of syndromic tufting enteropathy harbors SPINT2 mutation seen in congenital sodium diarrhea. Sivagnanam M, Janecke AR, Müller T, Heinz-Erian P, Taylor S, Bird LM, Clinical dysmorphology 2010 Jan 19 (1): 48. PMID: 20009592
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