|Application ||WB, E|
|Other Accession||NP_003967.2, NP_476501.1, NP_476431.2, 9048, 11876 (mouse), 362572 (rat)|
|Calculated MW||22878 Da|
|Other Names||Artemin, Enovin, Neublastin, ARTN, EVN|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARTN Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.|
|Tissue Location||Ubiquitous. Expressed at high levels in peripheral tissues including prostate, placenta, pancreas, heart, kidney, pituitary gland, lung and testis. Expressed at low levels in the brain.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoforms (NP_003967.2; NP_476501.1; NP_476431.2). Reported variants represent identical protein: NP_476431.2, NP_001129687.1 Reported variants represent identical protein: NP_003967.2, NP_476432.2
Artemin stimulates oncogenicity and invasiveness of human endometrial carcinoma cells. Pandey V, Qian PX, Kang J, Perry JK, Mitchell MD, Yin Z, Wu ZS, Liu DX, Zhu T, Lobie PE, Endocrinology 2010 Mar 151 (3): 909-20. PMID: 20118197
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