MOGAT2 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q3SYC2 |
Other Accession | NP_079374.2, 80168 |
Reactivity | Human |
Predicted | Pig, Dog, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 38196 Da |
Gene ID | 80168 |
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Other Names | 2-acylglycerol O-acyltransferase 2, 2.3.1.22, Acyl-CoA:monoacylglycerol acyltransferase 2, MGAT2, hMGAT2, Diacylglycerol O-acyltransferase candidate 5, hDC5, Diacylglycerol acyltransferase 2-like protein 5, Monoacylglycerol O-acyltransferase 2, MOGAT2, DC5, DGAT2L5 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MOGAT2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MOGAT2 (HGNC:23248) |
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Synonyms | DC5, DGAT2L5 |
Function | Involved in glycerolipid synthesis and lipid metabolism (PubMed:12621063, PubMed:18768481, PubMed:27184406, PubMed:28420705). Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol (PubMed:12621063, PubMed:27184406). Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes (By similarity). Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0 at sn-2 (PubMed:12621063). Able to use 1-monoalkylglycerol (1-MAkG, 1-O- alkylglycerol) as an acyl acceptor for the synthesis of monoalkyl- monoacylglycerol (MAMAG, 1-O-alkyl-3-acylglycerol or 1-O-alkyl-2- acylglycerol) and subsequently, with lower efficiency, may add another acyl chain producing monoalkyl-diacylglycerol (MADAG, 1-O-alkyl-2,3- diacylglycerol) (PubMed:28420705). Possesses weak but significant activity with diacylglycerol as substrate, producing triacylglycerol (triacyl-sn-glycerol) (PubMed:18768481). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region |
Tissue Location | Highly expressed in liver, small intestine, colon, stomach and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
References
A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet. Cao J, Hawkins E, Brozinick J, Liu X, Zhang H, Burn P, Shi Y, The Journal of biological chemistry 2004 Apr 279 (18): 18878-86. PMID: 14966132
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