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COPS3 Antibody (internal region)

Peptide-affinity purified goat antibody

  • WB - COPS3 Antibody (internal region) AF3344a
    HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human COPS3 with DYKDDDDK tag probed with AF3344a (1.0ug/ml) in Lane A and probed with anti-DYKDDDDK Tag (1/5000) in lane C. Mock-transfected HEK293 probed with AF3344a (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UNS2
Other Accession NP_003644.2, 8533, 26572 (mouse), 287367 (rat)
Reactivity Human
Predicted Mouse, Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 47873 Da
Additional Information
Gene ID 8533
Other Names COP9 signalosome complex subunit 3, SGN3, Signalosome subunit 3, JAB1-containing signalosome subunit 3, COPS3, CSN3
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCOPS3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COPS3
Synonyms CSN3
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed. Expressed at high level in heart and skeletal muscle.
Research Areas
Citations (0)

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ, Science (New York, N.Y.) 2007 May 316 (5828): 1160-6. PMID: 17525332

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$ 325.00
Cat# AF3344a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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