|Application ||IHC, E|
|Other Accession||NP_079513.1, 50964, 74499 (mouse), 80722 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||24031 Da|
|Other Names||Sclerostin, SOST|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SOST Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis. Huang QY, Li GH, Kung AW, Bone 2009 Aug 45 (2): 289-94. PMID: 19371798
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