|Application ||IHC, E|
|Other Accession||NP_079513.1, 50964, 74499 (mouse), 80722 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||24031 Da|
|Other Names||Sclerostin, SOST|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SOST Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level)|
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis. Huang QY, Li GH, Kung AW, Bone 2009 Aug 45 (2): 289-94. PMID: 19371798
If you have any additional inquiries please email technical services at firstname.lastname@example.org.