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GM2A (aa 164-175) Antibody (internal region)

Peptide-affinity purified goat antibody

  • WB - GM2A (aa 164-175) Antibody (internal region) AF3349a
    HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human GM2A with DYKDDDDK tag probed with AF3349a (1.0ug/ml) in Lane A and probed with anti- DYKDDDDK Tag (1/30000) in lane C. Mock-transfected HEK293 probed with AF3349a (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.
  • WB - GM2A (aa 164-175) Antibody (internal region) AF3349a
    AF3349a (0.3 µg/ml) staining of Rat Kidney lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17900
Other Accession NP_000396.2, 2760, 14667 (mouse), 282838 (rat)
Reactivity Human, Rat
Predicted Mouse, Rabbit
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 20838 Da
Additional Information
Gene ID 2760
Other Names Ganglioside GM2 activator, Cerebroside sulfate activator protein, GM2-AP, Sphingolipid activator protein 3, SAP-3, Ganglioside GM2 activator isoform short, GM2A
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGM2A (aa 164-175) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GM2A
Function The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
Cellular Location Lysosome.
Research Areas
Citations (0)

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This antibody is expected to recognize isoform 1 (NP_000396.2) only.


Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse. Todeschini AR, Dos Santos JN, Handa K, Hakomori SI, The Journal of biological chemistry 2007 Mar 282 (11): 8123-33. PMID: 17215249

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$ 325.00
Cat# AF3349a
(40 western blots)
Availability: 7-10 days
Bulk Size
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