|Application ||WB, E|
|Other Accession||NP_000396.2, 2760, 14667 (mouse), 282838 (rat)|
|Calculated MW||20838 Da|
|Other Names||Ganglioside GM2 activator, Cerebroside sulfate activator protein, GM2-AP, Sphingolipid activator protein 3, SAP-3, Ganglioside GM2 activator isoform short, GM2A|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GM2A (aa 164-175) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize isoform 1 (NP_000396.2) only.
Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse. Todeschini AR, Dos Santos JN, Handa K, Hakomori SI, The Journal of biological chemistry 2007 Mar 282 (11): 8123-33. PMID: 17215249
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