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TRIM72 Antibody (internal region)

Peptide-affinity purified goat antibody

  • WB - TRIM72 Antibody (internal region) AF3364a
    AF3364a (0.01 µg/ml) staining of Mouse Heart lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • IHC - TRIM72 Antibody (internal region) AF3364a
    AF3364a (3.8 µg/ml) staining of paraffin embedded Human Skeletal Muscle. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6ZMU5
Other Accession NP_001008275.1, 493829, 434246 (mouse), 365377 (rat)
Reactivity Human, Mouse, Rat
Predicted Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 52731 Da
Additional Information
Gene ID 493829
Other Names Tripartite motif-containing protein 72, Mitsugumin-53, Mg53, TRIM72 (HGNC:32671), MG53
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRIM72 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM72 (HGNC:32671)
Synonyms MG53
Function Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).
Cellular Location Cell membrane, sarcolemma. Cytoplasmic vesicle membrane. Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine.
Research Areas
Citations (0)

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Crystal structure of PRY-SPRY domain of human TRIM72. Park EY, Kwon OB, Jeong BC, Yi JS, Lee CS, Ko YG, Song HK, Proteins 2010 Feb 78 (3): 790-5. PMID: 19967786

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$ 325.00
Cat# AF3364a
(40 western blots)
Availability: 7-10 days
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