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DCTN3 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, Pep-ELISA |
|---|---|
| Primary Accession | O75935 |
| Other Accession | NP_009165.1, NP_077324.1, 11258, 53598 (mouse), 362504 (rat) |
| Reactivity | Human, Mouse, Rat |
| Predicted | Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 21119 Da |
| Gene ID | 11258 |
|---|---|
| Other Names | Dynactin subunit 3, Dynactin complex subunit 22 kDa subunit, p22, DCTN3 {ECO:0000312|EMBL:CAG46687.1}, DCTN22 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DCTN3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DCTN3 {ECO:0000312|EMBL:CAG46687.1} |
|---|---|
| Synonyms | DCTN22 |
| Function | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Together with dynein may be involved in spindle assembly and cytokinesis (PubMed:9722614). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells |
| Tissue Location | Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_009165.1; NP_077324.1).
References
Breast cancer molecular signatures as determined by SAGE: correlation with lymph node status. Abba MC, Sun H, Hawkins KA, Drake JA, Hu Y, Nunez MI, Gaddis S, Shi T, Horvath S, Sahin A, Aldaz CM. Mol Cancer Res. 2007 Sep;5(9):881-90. PMID: 17855657
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