|Application ||WB, E|
|Other Accession||NP_212133.1, 374882, 235043 (mouse), 300441 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||21198 Da|
|Other Names||Transmembrane protein 205, TMEM205|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TMEM205 (aa137-146) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.|
|Cellular Location||Membrane; Multi-pass membrane protein Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance|
|Tissue Location||Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_940938.1, NP_212133.1, NP_001138888.1
Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. Shen DW, Ma J, Okabe M, Zhang G, Xia D, Gottesman MM, J Cell Physiol. 2010 Nov;225(3):822-8. PMID: 20589834
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