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TMEM205 (aa137-146) Antibody (internal region)

Peptide-affinity purified goat antibody

     
  • WB - TMEM205 (aa137-146) Antibody (internal region) AF3378a
    AF3377a (0.03 µg/ml) staining of Human Pancreas lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q6UW68
Other Accession NP_212133.1, 374882, 235043 (mouse), 300441 (rat)
Reactivity Human
Predicted Mouse, Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 21198 Da
Additional Information
Gene ID 374882
Other Names Transmembrane protein 205, TMEM205
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTMEM205 (aa137-146) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM205
Function In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.
Cellular Location Membrane; Multi- pass membrane protein. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance
Tissue Location Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level)
Research Areas
Citations (0)
citation

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Background

Reported variants represent identical protein: NP_940938.1, NP_212133.1, NP_001138888.1

References

Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. Shen DW, Ma J, Okabe M, Zhang G, Xia D, Gottesman MM, J Cell Physiol. 2010 Nov;225(3):822-8. PMID: 20589834

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$ 341.00
Cat# AF3378a
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