TMEM205 (aa137-146) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q6UW68 |
Other Accession | NP_212133.1, 374882, 235043 (mouse), 300441 (rat) |
Reactivity | Human |
Predicted | Mouse, Rat, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 21198 Da |
Gene ID | 374882 |
---|---|
Other Names | Transmembrane protein 205, TMEM205 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TMEM205 (aa137-146) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TMEM205 |
---|---|
Function | In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin. |
Cellular Location | Membrane; Multi- pass membrane protein. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance |
Tissue Location | Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Reported variants represent identical protein: NP_940938.1, NP_212133.1, NP_001138888.1
References
Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. Shen DW, Ma J, Okabe M, Zhang G, Xia D, Gottesman MM, J Cell Physiol. 2010 Nov;225(3):822-8. PMID: 20589834
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