|Application ||WB, E|
|Other Accession||NP_116173.2, 84870, 72780 (mouse), 498997 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||30929 Da|
|Other Names||R-spondin-3, Protein with TSP type-1 repeat, hPWTSR, Roof plate-specific spondin-3, hRspo3, Thrombospondin type-1 domain-containing protein 2, RSPO3, PWTSR, THSD2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RSPO3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.|
|Tissue Location||Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node|
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Personalized smoking cessation: interactions between nicotine dose, dependence and quit success genotype score. Rose J, Behm FM, Drgon T, Johnson C, Uhl GR, Molecular medicine (Cambridge, Mass.) 2010 Mar : . PMID: 20379614
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