|Application ||WB, E|
|Other Accession||NP_001091868.1, NP_004362.2, 1314, 12847 (mouse), 304978 (rat)|
|Predicted||Mouse, Rat, Pig, Cow|
|Calculated MW||138346 Da|
|Other Names||Coatomer subunit alpha, Alpha-coat protein, Alpha-COP, HEP-COP, HEPCOP, Xenin, Xenopsin-related peptide, Proxenin, COPA|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COPA Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).|
|Cellular Location||Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it|
|Tissue Location||Uniformly expressed in a wide range of adult and fetal tissues. Xenin is found in gastric, duodenal and jejunal mucosa. Circulates in the blood. Seems to be confined to specific endocrine cells|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_001091868.1; NP_004362.2).
Yip1A regulates the COPI-independent retrograde transport from the Golgi complex to the ER. Kano F, Yamauchi S, Yoshida Y, Watanabe-Takahashi M, Nishikawa K, Nakamura N, Murata M, Journal of cell science 2009 Jul 122 (Pt 13): 2218-27. PMID: 19509059
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