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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > NEK7 (aa 274-286) Antibody (C-Term)
NEK7 (aa 274-286) Antibody (C-Term)
Peptide-affinity purified goat antibody
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Application 
| WB, E |
|---|---|
| Primary Accession | Q8TDX7 |
| Other Accession | NP_598001.1, 140609, 59125 (mouse), 360850 (rat) |
| Reactivity | Human, Mouse |
| Predicted | Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 34551 Da |
| Gene ID | 140609 |
|---|---|
| Other Names | Serine/threonine-protein kinase Nek7, 2.7.11.1, Never in mitosis A-related kinase 7, NimA-related protein kinase 7, NEK7 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NEK7 (aa 274-286) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NEK7 {ECO:0000303|PubMed:11701951, ECO:0000312|HGNC:HGNC:13386} |
|---|---|
| Function | Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132, PubMed:31409757, PubMed:19941817). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:17586473, PubMed:19414596, PubMed:31409757, PubMed:19941817, PubMed:26522158). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). Phosphorylates RPS6KB1 (By similarity). Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (PubMed:26642356, PubMed:36442502). Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (PubMed:26642356, PubMed:31189953, PubMed:36442502). Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (PubMed:26642356, PubMed:31189953). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9ES74}. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present at centrosome throughout the cell cycle (PubMed:17586473). Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (PubMed:17586473). Interaction with ANKS3 prevents its translocation to the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9ES74, ECO:0000269|PubMed:17586473} |
| Tissue Location | Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, Wang X, Pankratz VS, Fredericksen ZS, Vachon CM, Vierkant RA, Cerhan JR, Couch FJ, Breast Cancer Res Treat. 2011 Jan;125(1):221-8. PMID: 20508983
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$ 341.00
Cat# AF3392a
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