|Application ||WB, E|
|Other Accession||NP_598001.1, 140609, 59125 (mouse), 360850 (rat)|
|Predicted||Rat, Dog, Cow|
|Calculated MW||34551 Da|
|Other Names||Serine/threonine-protein kinase Nek7, 188.8.131.52, Never in mitosis A-related kinase 7, NimA-related protein kinase 7, NEK7|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NEK7 (aa 274-286) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present at centrosome throughout the cell cycle. Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody|
|Tissue Location||Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine|
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Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, Wang X, Pankratz VS, Fredericksen ZS, Vachon CM, Vierkant RA, Cerhan JR, Couch FJ, Breast Cancer Res Treat. 2011 Jan;125(1):221-8. PMID: 20508983
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