|Application ||WB, E|
|Other Accession||NP_038462.1, 30818|
|Calculated MW||29231 Da|
|Other Names||Calsenilin, A-type potassium channel modulatory protein 3, DRE-antagonist modulator, DREAM, Kv channel-interacting protein 3, KChIP3, KCNIP3, CSEN, DREAM, KCHIP3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNIP3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CSEN, DREAM, KCHIP3|
|Function||Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).|
|Cellular Location||Cytoplasm. Cell membrane; Lipid-anchor Endoplasmic reticulum. Golgi apparatus. Nucleus. Note=Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus|
|Tissue Location||Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize isoform 1 (NP_038462.1) only.
The DREAM protein is associated with thyroid enlargement and nodular development. Rivas M, Mellström B, Torres B, Cali G, Ferrara AM, Terracciano D, Zannini M, Morreale de Escobar G, Naranjo JR. Molecular endocrinology (Baltimore, Md.) 2009 Jun 23 (6): 862-70. PMID: 19299442
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