|Application ||IHC, E|
|Other Accession||NP_036586.2, 26230, 24001 (mouse)|
|Calculated MW||190103 Da|
|Other Names||T-lymphoma invasion and metastasis-inducing protein 2, TIAM-2, SIF and TIAM1-like exchange factor, TIAM2, KIAA2016, STEF|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TIAM2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.|
|Cellular Location||Cytoplasm. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites.|
|Tissue Location||Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize isoform a (NP_036586.2) only.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR, Molecular medicine (Cambridge, Mass.) 16 (7-8): 247-53. PMID: 20379614
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