|Application ||WB, E|
|Other Accession||NP_796376.2, 127833, 20980 (mouse), 24805 (rat)|
|Predicted||Human, Rat, Cow|
|Calculated MW||46872 Da|
|Other Names||Synaptotagmin-2, Synaptotagmin II, SytII, SYT2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Synaptotagmin-2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Note=Synaptic vesicles and chromaffin granules.|
|Tissue Location||Expressed in melanocytes (PubMed:23999003).|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_001129976.1, NP_796376.2
Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor. Young SM, Neher E, Neuron 2009 Aug 63 (4): 482-96. PMID: 19709630
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