|Application ||WB, E|
|Other Accession||NP_035006.3, 653361, 17969 (mouse), 114553 (rat)|
|Predicted||Human, Rat, Pig, Dog, Cow|
|Calculated MW||44652 Da|
|Other Names||Neutrophil cytosol factor 1, NCF-1, 47 kDa autosomal chronic granulomatous disease protein, 47 kDa neutrophil oxidase factor, NCF-47K, Neutrophil NADPH oxidase factor 1, Nox organizer 2, Nox-organizing protein 2, SH3 and PX domain-containing protein 1A, p47-phox, NCF1, NOXO2, SH3PXD1A|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||p47phox (mouse) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).|
|Cellular Location||Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Detected in peripheral blood monocytes and neutrophils (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (second update). Roos D, Kuhns DB, Maddalena A, Bustamante J, Kannengiesser C, de Boer M, van Leeuwen K, KÃ¶ker MY, Wolach B, Roesler J, Malech HL, Holland SM, Gallin JI, Stasia MJ, Blood cells, molecules & diseases 2010 Apr 44 (4): 291-9. PMID: 20167518
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