|Application ||WB, E|
|Other Accession||NP_056464.1, 26145|
|Reactivity||Human, Mouse, Rat|
|Predicted||Pig, Dog, Cow|
|Calculated MW||61688 Da|
|Other Names||Interferon regulatory factor 2-binding protein 1, IRF-2-binding protein 1, IRF-2BP1, Probable E3 ubiquitin-protein ligase IRF2BP1, 6.3.2.-, IRF2BP1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IRF2BP1 (aa461-474) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.|
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Provided below are standard protocols that you may find useful for product applications.
IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. Kimura M, FEBS letters 2008 Aug 582 (19): 2833-7. PMID: 18671972
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