|Application ||WB, E|
|Other Accession||NP_006130.1, 940|
|Calculated MW||25066 Da|
|Other Names||T-cell-specific surface glycoprotein CD28, TP44, CD28, CD28|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD28 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in T-cells and plasma cells, but not in less mature B-cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The immunizing peptide corresponds to a part of the extracellular domain.
New approach reveals CD28 and IFNG gene interaction in the susceptibility to cervical cancer. Guzman VB, Yambartsev A, Goncalves-Primo A, Silva ID, Carvalho CR, Ribalta JC, Goulart LR, Shulzhenko N, Gerbase-Delima M, Morgun A, Human molecular genetics 2008 Jun 17 (12): 1838-44. PMID: 18337305
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