|Application ||WB, E|
|Other Accession||NP_002063.2, 2776, 14682 (mouse), 81666 (rat)|
|Reactivity||Human, Mouse, Rat|
|Predicted||Pig, Cow, Dog|
|Calculated MW||42142 Da|
|Other Names||Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein alpha-q, GNAQ, GAQ|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GNAQ / ALPHA-q (aa162-175) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity).|
|Cellular Location||Nucleus. Membrane. Nucleus membrane. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.|
|Tissue Location||Predominantly expressed in ovary, prostate, testis and colon. Down-regulated in the peripheral blood lymphocytes (PBLs) of rheumatoid arthritis patients (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation. Ngai J, Inngjerdingen M, Berge T, TaskÃ©n K, BMC immunology 2009 10 : 27. PMID: 19426503
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