Foxi3 (mouse) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | D3Z120 |
Other Accession | NP_001094934.1, 232077 (mouse), 502846 (rat) |
Reactivity | Mouse, Rat |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 42015 Da |
Gene ID | 232077 |
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Other Names | Foxi3; forkhead box I3; forkhead box protein I3 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Foxi3 (mouse) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Foxi3 {ECO:0000303|PubMed:23441037, ECO:0000312|MGI:MGI:3511278} |
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Function | Transcription factor required for pharyngeal arch development, which is involved in hair, ear, jaw and dental development (PubMed:24650709, PubMed:26550799, PubMed:26992132, PubMed:30467319). May act as a pioneer transcription factor during pharyngeal arch development (PubMed:26550799, PubMed:26992132). Required for epithelial cell differentiation within the epidermis (PubMed:26450968). Acts at multiple stages of otic placode induction: necessary for preplacodal ectoderm to execute an inner ear program (PubMed:26550799). Required for hair follicle stem cell specification (PubMed:26992132). Acts downstream of TBX1 for the formation of the thymus and parathyroid glands from the third pharyngeal pouch (PubMed:31412026). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:30467319, ECO:0000269|PubMed:37041148} |
Tissue Location | Specifically expressed in the epithelium in developing ectodermal appendages (PubMed:23441037). Expressed in pharyngeal endoderm and ectoderm (PubMed:24650709). Expressed in pre- placodal ectoderm (PubMed:26550799). Down-regulated as the otic placode is induced (PubMed:26550799). Expressed in teeth and hair follicles throughout embryogenesis (PubMed:23441037). Expressed in mammary glands only during the earliest stages of development (PubMed:23441037) |
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Provided below are standard protocols that you may find useful for product applications.
References
A mutation in hairless dogs implicates FOXI3 in ectodermal development. Drögemüller C, Karlsson EK, Hytönen MK, Perloski M, Dolf G, Sainio K, Lohi H, Lindblad-Toh K, Leeb T, Science (New York, N.Y.) 2008 Sep 321 (5895): 1462. PMID: 18787161
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