|Other Accession||NP_078780.1, 63978, 383491 (mouse), 100365184 (rat)|
|Predicted||Human, Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||64062 Da|
|Other Names||PR domain zinc finger protein 14, 2.1.1.-, PR domain-containing protein 14, PRDM14|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRDM14 (aa414-427) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.|
|Tissue Location||Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level)|
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A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia NY, Chan YS, Feng B, Lu X, Orlov YL, Moreau D, Kumar P, Yang L, Jiang J, Lau MS, Huss M, Soh BS, Kraus P, Li P, Lufkin T, Lim B, Clarke ND, Bard F, Ng HH, Nature. 2010 Nov 11;468(7321):316-20.. PMID: 20953172
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